[1]	NUCLEOTIDE SEQUENCE. TISSUE=Leaf; Kiefer M., Cushman J.C., Ratajczak R., Haag-Kerwer A.; "A putative phospholipid hydroperoxide glutathione peroxidase from the common ice plant Mesembryanthemum crystallinum."; Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (By similarity).
CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H₂O.
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the glutathione peroxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ250951; CAB96145.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ315976; CAC83045.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00435; 1GP1. [HSSP ENTRY / PDB]

ModBase

Q9LEF0.

Protein family/group databases

PeroxiBase

2866; McGPx06.

Ontologies

GO:0047066;	Molecular function: phospholipid-hydroperoxide glutathione peroxidase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR000889; Glut_peroxidase.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.30.10; Thioredoxin_fold; 1.

PANTHER

PTHR11592; Glut_peroxidase; 1.

Pfam

PF00255; GSHPx; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000303; Glutathion_perox; 1.

PRINTS

PR01011; GLUTPROXDASE.

ProDom

PD003679; Thioredoxin_like; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00460; GLUTATHIONE_PEROXID_1; 1.
PS00763; GLUTATHIONE_PEROXID_2; 1.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 170`	`170`	`Probable phospholipid hydroperoxide glutathione peroxidase.`	`PRO_0000066632`
`ACT_SITE`	`44 44`		`By similarity.`

Sequence information

Length: 170 AA [This is the length of the unprocessed precursor]

Molecular weight: 18917 Da [This is the MW of the unprocessed precursor]

CRC64: 10FBD855BBFC4798 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASQSTDQPK SIHDFIVKDA RGNDVDLSIY KGKVLLIVNV ASQCGLTNSN YPELTKLYEQ 

        70         80         90        100        110        120 
YKDKGLEILA FPCNQFGNQE PGDNEQIMEF ACTRFKAEFP IFDKVDVNGS NAAPVYKYLK 

       130        140        150        160        170 
SSKGGLFGDG IKWNFTKFLV DRDGKVVDRY APTTSPASIE KDIKKLIGTS

Q9LEF0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools