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UniProtKB/Swiss-Prot entry Q9S2B5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_STRCO
Primary accession number Q9S2B5
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
Synonyms: hgd
OrderedLocusNames: SCO1715
ORFNames: SCI11.04
From
Streptomyces coelicolor [TaxID: 1902] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-471 / A3(2) / M145;
DOI=10.1038/417141a; PubMed=12000953 [NCBI, ExPASy, EBI, Israel, Japan]
Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).";
Nature 417:141-147(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL939110; CAB50930.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T36737; T36737.
RefSeq NP_625988.1; -.
3D structure databases
HSSP Q93099; 1EYB. [HSSP ENTRY / PDB]
ModBase Q9S2B5.
Enzyme and pathway databases
BioCyc SCOE100226:SCO1715-MON; -.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q9S2B5.
Genome annotation databases
GeneID 1097146; -.
GenomeReviews AL645882_GR; SCO1715.
KEGG sco:SCO1715; -.
NMPDR fig|100226.1.peg.1682; -.
Phylogenomic databases
HOGENOM Q9S2B5; -.
Genome annotation databases
CMR Q9S2B5; SCO1715.
Other
ProtoNet Q9S2B5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   441  441     Homogentisate 1,2-dioxygenase. PRO_0000220256
METAL   340   340        Iron (By similarity). 
METAL   346   346        Iron (By similarity). 
METAL   376   376        Iron (By similarity). 
Sequence information
Length: 441 AA [This is the length of the unprocessed precursor] Molecular weight: 48418 Da [This is the MW of the unprocessed precursor] CRC64: 52161616024FFD5F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSGDARKTAE GLAYLSGFGN EHASEAVAGA LPEGRNSPQR APLGLYAEQL SGTAFTEPRA 

        70         80         90        100        110        120 
HNRRSWLYRI RPSAAHPAFT RSGNGTIRTA PFNQAVPDPN RLRWNPLPVP GPATDFVEGL 

       130        140        150        160        170        180 
WTLGGNGDAT QRTGMAVHLY HATASMDRVF SDADGELLIV PERGGLLLRT EFGLLHAEPG 

       190        200        210        220        230        240 
HVALIPRGVR FRVQLLDEDA RGYVCENYGA PFQLPDLGPI GANGLANARD FRAPVAAYED 

       250        260        270        280        290        300 
DESTPGPVEV VNKFCGNLWT AEYDHSPLDV VAWHGNHVPY VYDLRRFNVI GSISYDHPDP 

       310        320        330        340        350        360 
SIFTVLTSPS DTPGLAGVDF VVFAPRWLVG EDTFRPPYFH RNVMSEYMGL IEGAYDAKAE 

       370        380        390        400        410        420 
GFVPGGGSLH NMMSAHGPDR ETFDRASAAE LKPQRIDDGL AFMFETRWPV TLTPQAARAE 

       430        440 
HLQPGYDDVW QGLERHFRPL H
Q9S2B5 in FASTA format

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