NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NIES-484;
DOI=10.1105/tpc.11.9.1717; PubMed=10488238 [NCBI, ExPASy, EBI, Israel, Japan]
Turmel M., Lemieux C., Burger G., Lang B.F., Otis C., Plante I., Gray M.W.;
"The complete mitochondrial DNA sequences of Nephroselmis olivacea and Pedinomonas minor: two radically different evolutionary patterns within the green algae.";
Plant Cell 11:1717-1730(1999).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF110138; AAF03201.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_665674.1; -.

3D structure databases

ModBase

Q9TC96.

Ontologies

GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01962; NuoD; 1.

PROSITE

PS00535; COMPLEX1_49K; 1.

BLOCKS

Q9TC96.

Genome annotation databases

GeneID

4178038; -.

Other

ProtoNet

Q9TC96.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 398`	`398`	`NADH-ubiquinone oxidoreductase 49 kDa subunit.`	`PRO_0000118584`
`METAL`	`261 261`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`267 267`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`282 282`		`Iron-sulfur (4Fe-4S) (Potential).`

Sequence information

Length: 398 AA [This is the length of the unprocessed precursor]

Molecular weight: 45476 Da [This is the MW of the unprocessed precursor]

CRC64: BCBD8FE4AACB08EB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAIEHASSIK KVKNFTLNFG PQHPAAHGVL RLVLELNGEV VARADPHIGL LHRGTEKLIE 

        70         80         90        100        110        120 
YKTYTQALPY FDRLDYVSMM CQEHAYSLAV EKLLHCEVPE RAQYIRVLFS EITRILNHLL 

       130        140        150        160        170        180 
ALTTHAMDVG ALTPFLWAFE EREKLIEFYE RVSGSRMHAA YIRPGGVACD LPANLCEDIY 

       190        200        210        220        230        240 
LFCQQFASRI DEMEEMLTNN RIWKQRLVDI GIVTAENAFA WGFSGVLLRG SGVAWDLRKT 

       250        260        270        280        290        300 
QPYDVYNRMI FDVPVGTQGD CYDRYLCRVE EMRQSIHIIM QCLNQLPKGM IKADDKKITP 

       310        320        330        340        350        360 
PSRSQMKQSM ESLIHHFKLF TEGYTVPNSE TYTSVEAPKG EFGVYLVSNG TNRPYRCKIR 

       370        380        390 
APGFLHLQGL DMMSKNHMLA DVVTIIGTQD IVFGEVDR

Q9TC96 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools