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UniProtKB/Swiss-Prot entry Q9UJM8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HAOX1_HUMAN
Primary accession number Q9UJM8
Secondary accession numbers Q14CQ0 Q9UPZ0 Q9Y3I7
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 73)
Name and origin of the protein
Protein name Hydroxyacid oxidase 1
Synonyms HAOX1
EC 1.1.3.15
Glycolate oxidase
GOX
Gene name
Name: HAO1
Synonyms: GOX1, HAOX1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1016/S0167-4781(00)00161-5; PubMed=10978532 [NCBI, ExPASy, EBI, Israel, Japan]
Williams E.L., Cregeen D.P., Rumsby G.;
"Identification and expression of a cDNA for human glycolate oxidase.";
Biochim. Biophys. Acta 1493:246-248(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.275.17.12590; PubMed=10777549 [NCBI, ExPASy, EBI, Israel, Japan]
Jones J.M., Morrell J.C., Gould S.J.;
"Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases.";
J. Biol. Chem. 275:12590-12597(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Stavrides G.S., Huckle E.J., Deloukas P.;
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA].
Watanabe T.;
"Isolation and characterization of a novel human liver-specific gene homologous to the plant glycolate oxidase by the differential display method.";
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF244134; AAF63219.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF231916; AAF40199.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL121739; CAB57329.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB024079; BAA82872.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL021879; CAC34364.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC113665; AAI13666.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC113667; AAI13668.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_060015.1; -.
UniGene Hs.193640
3D structure databases
PDB
2NZL; X-ray; 1.35 A; A=1-370.[ExPASy / RCSB / EBI]
2RDT; X-ray; 1.95 A; A=1-370.[ExPASy / RCSB / EBI]
2RDU; X-ray; 1.65 A; A=1-370.[ExPASy / RCSB / EBI]
2RDW; X-ray; 1.95 A; A=1-370.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2NZL; -.
2RDT; -.
2RDU; -.
2RDW; -.
ModBase Q9UJM8.
PTM databases
PhosphoSite Q9UJM8; -.
Organism-specific databases
H-InvDB HIX0040489; -.
HGNC HGNC:4809; HAO1.
GenAtlas HAO1.
MIM 605023; gene. [NCBI / EBI]
PharmGKB PA29185; -.
GeneCards Q9UJM8.
Gene expression databases
ArrayExpress Q9UJM8; -.
CleanEx HS_HAO1; -.
GermOnline ENSG00000101323; Homo sapiens.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (traceable author statement from UniProtKB).
GO:0003973; Molecular function: (S)-2-hydroxy-acid oxidase activity (traceable author statement from UniProtKB).
GO:0001561; Biological process: fatty acid alpha-oxidation (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR012133; Alpha_OHA_DHase_FMN.
IPR008259; FMN_hydac_DHase_AS.
IPR000262; FMN_OHA_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01070; FMN_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000138; Al-hdrx_acd_dh; 1.
PROSITE PS00557; FMN_HYDROXY_ACID_DH_1; 1.
PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9UJM8.
Genome annotation databases
Ensembl ENSG00000101323; Homo sapiens. [Contig view]
GeneID 54363; -.
KEGG hsa:54363; -.
Phylogenomic databases
HOGENOM Q9UJM8; -.
HOVERGEN Q9UJM8; -.
Other
SOURCE HAO1; Homo sapiens.
ProtoNet Q9UJM8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Flavoprotein; FMN; Glycolate pathway; Oxidoreductase; Peroxisome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   370  370     Hydroxyacid oxidase 1. PRO_0000206318
DOMAIN   1   365  365     FMN hydroxy acid dehydrogenase. 
NP_BIND   291   315  25     FMN (By similarity). 
MOTIF   368   370  3     Microbody targeting signal (Potential). 
ACT_SITE   260   260        Proton acceptor (By similarity). 
BINDING   26    26        Substrate (Potential). 
BINDING   108   108        FMN (By similarity). 
BINDING   130   130        FMN (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   158   158        FMN (By similarity). 
BINDING   167   167        Substrate (By similarity). 
BINDING   236   236        FMN (By similarity). 
BINDING   263   263        Substrate (Potential). 
HELIX   8    18  11      
HELIX   21    28  8      
HELIX   35    46  12      
STRAND   47    49  3      
STRAND   64    66  3      
STRAND   69    77  9      
HELIX   83    85  3      
HELIX   90   101  12      
STRAND   104   107  4      
HELIX   115   121  7      
STRAND   125   131  7      
STRAND   134   136  3      
HELIX   137   149  13      
STRAND   155   158  4      
HELIX   168   173  6      
HELIX   205   212  8      
HELIX   219   225  7      
STRAND   233   238  6      
HELIX   241   249  9      
STRAND   254   257  4      
HELIX   260   262  3      
HELIX   271   282  12      
STRAND   285   290  6      
HELIX   297   305  9      
STRAND   309   313  5      
HELIX   315   346  32      
HELIX   352   354  3      
HELIX   357   359  3      
Sequence information
Length: 370 AA [This is the length of the unprocessed precursor] Molecular weight: 40924 Da [This is the MW of the unprocessed precursor] CRC64: C683C6F7CB5FD323 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLPRLICIND YEQHAKSVLP KSIYDYYRSG ANDEETLADN IAAFSRWKLY PRMLRNVAET 

        70         80         90        100        110        120 
DLSTSVLGQR VSMPICVGAT AMQRMAHVDG ELATVRACQS LGTGMMLSSW ATSSIEEVAE 

       130        140        150        160        170        180 
AGPEALRWLQ LYIYKDREVT KKLVRQAEKM GYKAIFVTVD TPYLGNRLDD VRNRFKLPPQ 

       190        200        210        220        230        240 
LRMKNFETST LSFSPEENFG DDSGLAAYVA KAIDPSISWE DIKWLRRLTS LPIVAKGILR 

       250        260        270        280        290        300 
GDDAREAVKH GLNGILVSNH GARQLDGVPA TIDVLPEIVE AVEGKVEVFL DGGVRKGTDV 

       310        320        330        340        350        360 
LKALALGAKA VFVGRPIVWG LAFQGEKGVQ DVLEILKEEF RLAMALSGCQ NVKVIDKTLV 

       370 
RKNPLAVSKI 

Q9UJM8 in FASTA format

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