[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Umbilical vein; DOI=10.1016/S0960-9822(99)80093-1; PubMed=10074428 [NCBI, ExPASy, EBI, Israel, Japan] Gurney A.L., Marsters S.A., Huang R.M., Pitti R.M., Mark D.T., Baldwin D.T., Gray A.M., Dowd A.D., Brush A.D., Heldens A.D., Schow A.D., Goddard A.D., Wood W.I., Baker K.P., Godowski P.J., Ashkenazi A.; "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR."; Curr. Biol. 9:215-218(1999).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan] Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."; Genome Res. 13:2265-2270(2003).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 9-177. TISSUE=Brain; DOI=10.1074/jbc.274.10.6056; PubMed=10037686 [NCBI, ExPASy, EBI, Israel, Japan] Kwon B., Yu K.-Y., Ni J., Yu G.-L., Jang I.-K., Kim Y.-J., Xing L., Liu D., Wang S.-X., Kwon B.S.; "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."; J. Biol. Chem. 274:6056-6061(1999).

Comments

FUNCTION: Cytokine that binds to TNFRSF18/AITR/GITR. Important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues.
SUBUNIT: Homotrimer (Potential).
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
TISSUE SPECIFICITY: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
INDUCTION: Up-regulated after stimulation by lipopolysaccharides.
SIMILARITY: Belongs to the tumor necrosis factor family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF125303; AAD22634.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358868; AAQ89227.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069111; AAH69111.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF117713; AAD19695.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00009195; -.

UniGene

Hs.248197

3D structure databases

PDB

2Q1M; X-ray; 2.30 A; A=52-177.	[ExPASy / RCSB / EBI]
2R30; X-ray; 3.20 A; A=52-177.	[ExPASy / RCSB / EBI]
2R32; X-ray; 1.95 A; A=52-177.	[ExPASy / RCSB / EBI]
3B93; X-ray; 2.20 A; A/B/C=50-177.	[ExPASy / RCSB / EBI]
3B94; X-ray; 2.50 A; A/B/C/D=50-177.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

2Q1M; -.
2R30; -.
2R32; -.
3B93; -.
3B94; -.

ModBase

Q9UNG2.

Organism-specific databases

GC01M171275; -.

HIX0028550; -.

HGNC:11932; TNFSF18.

HPA012699; -.

603898; gene. [NCBI / EBI]

PharmGKB

PA36624; -.

Gene expression databases

Q9UNG2; -.

Q9UNG2; -.

HS_TNFSF18; -.

ENSG00000120337; Homo sapiens.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005125;	Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005164;	Molecular function: tumor necrosis factor receptor binding (inferred from electronic annotation from InterPro).
GO:0006916;	Biological process: anti-apoptosis (traceable author statement from ProtInc).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0006955;	Biological process: immune response (inferred from electronic annotation from InterPro).
GO:0007165;	Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR006052; TNF_family.
Graphical view of domain structure.

Pfam

PF00229; TNF; 1.
Pfam graphical view of domain structure.

PROSITE

PS00251; TNF_1; FALSE_NEG.
PS50049; TNF_2; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSG00000120337; Homo sapiens. [Contig view]

Phylogenomic databases

HOGENOM

Q9UNG2; -.

HOVERGEN

Q9UNG2; -.

Other

SOURCE

TNFSF18; Homo sapiens.

ProtoNet

Q9UNG2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Cytokine; Glycoprotein; Membrane; Signal-anchor; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 177`	`177`	`Tumor necrosis factor ligand superfamily member 18.`	`PRO_0000185506`
`TOPO_DOM`	`1 28`	`28`	`Cytoplasmic (Potential).`
`TRANSMEM`	`29 49`	`21`	`Signal-anchor for type II membrane protein (Potential).`
`TOPO_DOM`	`50 177`	`128`	`Extracellular (Potential).`
`CARBOHYD`	`129 129`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`161 161`		`N-linked (GlcNAc...) (Potential).`
`HELIX`	`20 46`	`27`
`STRAND`	`59 62`	`4`
`STRAND`	`69 72`	`4`
`STRAND`	`78 83`	`6`
`STRAND`	`86 89`	`4`
`STRAND`	`93 101`	`9`
`STRAND`	`115 119`	`5`
`STRAND`	`122 127`	`6`
`STRAND`	`130 132`	`3`
`STRAND`	`138 142`	`5`
`STRAND`	`147 154`	`8`
`HELIX`	`155 157`	`3`
`STRAND`	`164 171`	`8`

Sequence information

Length: 177 AA [This is the length of the unprocessed precursor]

Molecular weight: 20308 Da [This is the MW of the unprocessed precursor]

CRC64: 3D78CE6B90F4C9E3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCLSHLENMP LSHSRTQGAQ RSSWKLWLFC SIVMLLFLCS FSWLIFIFLQ LETAKEPCMA 

        70         80         90        100        110        120 
KFGPLPSKWQ MASSEPPCVN KVSDWKLEIL QNGLYLIYGQ VAPNANYNDV APFEVRLYKN 

       130        140        150        160        170 
KDMIQTLTNK SKIQNVGGTY ELHVGDTIDL IFNSEHQVLK NNTYWGIILL ANPQFIS

Q9UNG2 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools