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UniProtKB/Swiss-Prot entry Q9WU19

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HAOX1_MOUSE
Primary accession number Q9WU19
Secondary accession numbers None
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Hydroxyacid oxidase 1
Synonyms HAOX1
EC 1.1.3.15
Glycolate oxidase
GOX
Gene name
Name: Hao1
Synonyms: Gox1, Hao-1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1074/jbc.274.4.2401; PubMed=9891009 [NCBI, ExPASy, EBI, Israel, Japan]
Kohler S.A., Menotti E., Kuhn L.C.;
"Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA.";
J. Biol. Chem. 274:2401-2407(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF104312; AAD25332.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_034533.1; -.
UniGene Mm.26634
3D structure databases
HSSP P05414; 1AL8. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
SMR Q9WU19; 4-361.
ModBase Q9WU19.
PTM databases
PhosphoSite Q9WU19; -.
Organism-specific databases
MGI MGI:96011; Hao1.
Gene expression databases
ArrayExpress Q9WU19; -.
CleanEx MM_HAO1; -.
GermOnline ENSMUSG00000027261; Mus musculus.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (inferred from direct assay from HGNC).
GO:0003973; Molecular function: (S)-2-hydroxy-acid oxidase activity (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR012133; Alpha_OHA_DHase_FMN.
IPR008259; FMN_hydac_DHase_AS.
IPR000262; FMN_OHA_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01070; FMN_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000138; Al-hdrx_acd_dh; 1.
PROSITE PS00557; FMN_HYDROXY_ACID_DH_1; 1.
PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9WU19.
Genome annotation databases
Ensembl ENSMUSG00000027261; Mus musculus. [Contig view]
GeneID 15112; -.
KEGG mmu:15112; -.
NMPDR fig|10090.3.peg.6979; -.
Phylogenomic databases
HOGENOM Q9WU19; -.
HOVERGEN Q9WU19; -.
Other
SOURCE Hao1; Mus musculus.
ProtoNet Q9WU19.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Flavoprotein; FMN; Glycolate pathway; Oxidoreductase; Peroxisome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   370  370     Hydroxyacid oxidase 1. PRO_0000206319
DOMAIN   1   365  365     FMN hydroxy acid dehydrogenase. 
NP_BIND   291   315  25     FMN (By similarity). 
MOTIF   368   370  3     Microbody targeting signal (Potential). 
ACT_SITE   260   260        Proton acceptor (By similarity). 
BINDING   26    26        Substrate (Potential). 
BINDING   108   108        FMN (By similarity). 
BINDING   130   130        FMN (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   158   158        FMN (By similarity). 
BINDING   167   167        Substrate (By similarity). 
BINDING   236   236        FMN (By similarity). 
BINDING   263   263        Substrate (Potential). 
Sequence information
Length: 370 AA [This is the length of the unprocessed precursor] Molecular weight: 41001 Da [This is the MW of the unprocessed precursor] CRC64: 97339211AF9FC19C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLPRLVCISD YEQHVRSVLQ KSVYDYYRSG ANDQETLADN IQAFSRWKLY PRMLRNVADI 

        70         80         90        100        110        120 
DLSTSVLGQR VSMPICVGAT AMQCMAHVDG ELATVRACQT MGTGMMLSSW ATSSIEEVAE 

       130        140        150        160        170        180 
AGPEALRWMQ LYIYKDREIS RQIVKRAEKQ GYKAIFVTVD TPYLGNRIDD VRNRFKLPPQ 

       190        200        210        220        230        240 
LRMKNFETND LAFSPKGNFG DNSGLAEYVA QAIDPSLSWD DITWLRRLTS LPIVVKGILR 

       250        260        270        280        290        300 
GDDAKEAVKH GVDGILVSNH GARQLDGVPA TIDVLPEIVE AVEGKVEVFL DGGVRKGTDV 

       310        320        330        340        350        360 
LKALALGAKA VFVGRPIIWG LAFQGEKGVQ DVLEILKEEF RLAMALSGCQ NVKVIDKTLV 

       370 
RKNPLAVSKI
Q9WU19 in FASTA format

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