NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6, and PRO/RE;
TISSUE=Cerebellum;
DOI=10.1038/7777; PubMed=10192398 [NCBI, ExPASy, EBI, Israel, Japan]
Gogos J.A., Santha M., Takacs Z., Beck K.D., Luine V., Lucas L.R., Nadler J.V., Karayiorgou M.;
"The gene encoding proline dehydrogenase modulates sensorimotor gating in mice.";
Nat. Genet. 21:434-439(1999).

Comments

FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY: L-proline + acceptor + H₂O = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
COFACTOR: FAD.
PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2 .
SUBCELLULAR LOCATION: Mitochondrion matrix.
TISSUE SPECIFICITY: Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle.
DISEASE: Pro/re mice that have a premature termination on Prodh are sluggish in their movement.
SIMILARITY: Belongs to the proline oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF120279; AAD24776.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Mm.28456

3D structure databases

ModBase

Q9WU79.

Organism-specific databases

MGI

MGI:97770; Prodh.

Gene expression databases

CleanEx

MM_PRODH; -.

GermOnline

ENSMUSG00000003526; Mus musculus.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR002872; Proline_DHase.
IPR015659; Proline_oxidase.
Graphical view of domain structure.

PANTHER

PTHR13914; Proline_oxidase; 1.

Pfam

PF01619; Pro_dh; 1.
Pfam graphical view of domain structure.

BLOCKS

Q9WU79.

Genome annotation databases

Ensembl

ENSMUSG00000003526; Mus musculus. [Contig view]

Phylogenomic databases

HOVERGEN

Q9WU79; -.

Other

Prodh; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Proline metabolism; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 497`		`Proline oxidase, mitochondrial.`	`PRO_0000025801`

Sequence information

Length: 497 AA [This is the length of the unprocessed precursor]

Molecular weight: 56774 Da [This is the MW of the unprocessed precursor]

CRC64: 9B5C80FBBE8C3589 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFERLMKMTF YGHFVAGEDQ ESIRPLIRHN KAFGVGFILD YGVEEDLSPE EAERKEMESC 

        70         80         90        100        110        120 
TSEAERDGSG ANKREKQYQV HPAFGDRRDG VISARTYFYA NEAKCDNYME NLLQCIKASG 

       130        140        150        160        170        180 
GASDGGFSAI KLTALGRPQF LLQFSDVLTR WRRFFHQMAA EQGQAGRAAV DTKLEVAVLQ 

       190        200        210        220        230        240 
DSIAKMGIAS RAEIEGWFTP ETLGVSGTVD LLDWNSLIDS RTRLSRHLVV PNVQTGQLEP 

       250        260        270        280        290        300 
LLSRFTEEEE QQMKRMLQRM DVLAKKAKEA GVRLMIDAEQ SYFQPAISRL TLEMQRRFNV 

       310        320        330        340        350        360 
DKPFIFNTFQ CYLKDAYDNV TLDMELARRE GWCSGAKLVR RAYMAQERVR AAEIGYEDPI 

       370        380        390        400        410        420 
NPTYEATNAM YHRCLNYVLE ELKHSTKAEV MVASHNEDTV HFTLCRMKEI GLHPADGQVC 

       430        440        450        460        470        480 
FGQLLGMCDQ ISFPLGQAGF PVYKYVPYGP VMEVLPYLSR RALENSSIMK GAQRERQLLW 

       490 
QELRRRLRTG SLFHHPA

Q9WU79 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools