[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=AM511; Amemura-Maekawa J., Watanabe H.; "Legionella pneumophila catalase-peroxidase gene."; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity).
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
CATALYTIC ACTIVITY: Donor + H₂O₂ = oxidized donor + 2 H₂O.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per dimer (By similarity).
SUBUNIT: Homodimer or homotetramer (By similarity).
PTM: The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme (By similarity).
SIMILARITY: Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB017595; BAA78342.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

O59651; 1ITK. [HSSP ENTRY / PDB]

ModBase

Q9WXB9.

Family and domain databases

InterPro

IPR000763; Catalase_proxase.
IPR002016; Haem_peroxidase_pln/fun/bac.
Graphical view of domain structure.

Pfam

PF00141; peroxidase; 2.
Pfam graphical view of domain structure.

PRINTS

PR00460; BPEROXIDASE.
PR00458; PEROXIDASE.

TIGRFAMs

TIGR00198; cat_per_HPI; 1.

PROSITE

PS00435; PEROXIDASE_1; 1.
PS00436; PEROXIDASE_2; 1.
PS50873; PEROXIDASE_4; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 749`	`749`	`Peroxidase/catalase.`	`PRO_0000055569`
`ACT_SITE`	`108 108`		`Proton acceptor (By similarity).`
`METAL`	`270 270`		`Iron (heme axial ligand) (By similarity).`
`SITE`	`104 104`	`1`	`Transition state stabilizer (By similarity).`
`CROSSLNK`	`107 229`		`Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255) (By similarity).`
`CROSSLNK`	`229 255`		`Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107) (By similarity).`

Sequence information

Length: 749 AA [This is the length of the unprocessed precursor]

Molecular weight: 82915 Da [This is the MW of the unprocessed precursor]

CRC64: 19E7931C472973C8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFKRTIPLFA AFTLAISPSI FPNYAHAQED KPKTNQYWWP KMLDLSPLRQ PNATSNPMGE 

        70         80         90        100        110        120 
KFNYAEEFNS LDLNAVIEDL KKLMTTSQDW WPADYGNYGP LFIRMSWHAA GTYRIYDGRG 

       130        140        150        160        170        180 
GANGGFQRFA PQNSWPDNAN LDKARRLLWP IKQKYGRKIS WADLLVLAGN VAMESMGFKT 

       190        200        210        220        230        240 
IGFAGGREDA WEAININWGP EGKWLESKRQ DKDGKLEKPL AATVMGLIYV NPEGPNGVPD 

       250        260        270        280        290        300 
PLAAAEKIRE TFGRMAMNDE ETVALIAGGH AFGKTHGAAS GKYLGPAPEA AGIEEQGFGW 

       310        320        330        340        350        360 
KNSYGSGKGK DTITSGLEGA WTVTPTHWSH NYLQNLFNFN WVKTKSPGGA IQWVPENSNA 

       370        380        390        400        410        420 
SSMVPDAFDP SKRHAPVMLT TDLALKFDPV YSKIAKRFLD NPKEFDDAFA RAWFKLIHRD 

       430        440        450        460        470        480 
MGPRSRYLGS LVPKEAMIWQ DPVPPVDYKL VDANDIANLK GKILNSGLTT SELVKTAWAS 

       490        500        510        520        530        540 
ASTFRGTDMR GGANGARIRL APQKDWPAND PQELAKVLKT LESIQNNFNN AQADGKKISL 

       550        560        570        580        590        600 
ADLIVLGGNA AIEQAAKQAG YDIIVPFTPG RTDATQGMTD VKSFEVLEPK ADGFRNYFDK 

       610        620        630        640        650        660 
SNNMSPPEML VEKASLLKLS VPEMTVLVGG MRVLNANTGQ NQYGVFTDKP GTLNNDFFIN 

       670        680        690        700        710        720 
LLSMSTEWKK SSETEGIYEG YERKTGKLKW KATSVDLIFG ANSELRAVAE AYATDDAKEK 

       730        740 
FIQDFINAWV KVMTADRFDI KAANANINS

Q9WXB9 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools