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UniProtKB/Swiss-Prot entry Q9X4G0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_PSEAE
Primary accession number Q9X4G0
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on December 8, 2000 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 50)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
OrderedLocusNames: PA2009
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-236.
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
Beatson S.A., Whitchurch C.B., Mattick J.S.;
"Genes encoding phenylalanine catabolism in Pseudomonas aeruginosa.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE004091; AAG05397.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF109214; AAD23385.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F83394; F83394.
RefSeq NP_250699.1; -.
3D structure databases
HSSP Q93099; 1EYB. [HSSP ENTRY / PDB]
ModBase Q9X4G0.
Enzyme and pathway databases
BioCyc PAER208964:PA2009-MON; -.
Organism-specific databases
PseudoCAP PA2009; -.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q9X4G0.
Genome annotation databases
GeneID 877745; -.
GenomeReviews AE004091_GR; PA2009.
KEGG pae:PA2009; -.
Phylogenomic databases
HOGENOM Q9X4G0; -.
Genome annotation databases
CMR Q9X4G0; PA2009.
Other
ProtoNet Q9X4G0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   432  432     Homogentisate 1,2-dioxygenase. PRO_0000220249
METAL   330   330        Iron (By similarity). 
METAL   336   336        Iron (By similarity). 
METAL   366   366        Iron (By similarity). 
Sequence information
Length: 432 AA [This is the length of the unprocessed precursor] Molecular weight: 47841 Da [This is the MW of the unprocessed precursor] CRC64: 44B17EC2A0811E2A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNLDSTALAY QSGFGNEFSS EALPGALPVG QNSPQKAPYG LYAELLSGTA FTMARSEARR 

        70         80         90        100        110        120 
TWLYRITPSA KHPPFRRLER QIAGAELDAP TPNRLRWDPL ALPEQPTDFL DGLLRMAANA 

       130        140        150        160        170        180 
PGDKPAGVSI YQYLANRSME RCFYDADGEL LLVPQLGRLR LCTELGALQV EPLEIAVIPR 

       190        200        210        220        230        240 
GMKFRVELLD GEARGYIAEN HGAPLRLPDL GPIGSNGLAN PRDFLTPVAR YEDSRQPLQL 

       250        260        270        280        290        300 
VQKYLGELWA CELDHSPLDV VAWHGNNVPY KYDLRRFNTI GTVSFDHPDP SIFTVLTSPT 

       310        320        330        340        350        360 
SVPGLANIDF VIFPPRWMVA ENTFRPPWFH RNLMNEFMGL IQGAYDAKAG GFVPGGASLH 

       370        380        390        400        410        420 
SCMSAHGPDA ESCDKAIAAD LKPHRIDQTM AFMFETSQVL RPSRAALETP ALQNDYDACW 

       430 
ASLVSTFNPQ RR
Q9X4G0 in FASTA format

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