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UniProtKB/Swiss-Prot entry Q9Y041

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_CAEEL
Primary accession number Q9Y041
Secondary accession numbers O62087 Q9NJP3
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on April 27, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisic acid oxidase
Homogentisate oxygenase
Homogentisicase
Gene name
Name: hgo-1
ORFNames: W06D4.1
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Bristol N2;
Schmidt S.R., Werner E., Mueller C.R., Kress W.;
"Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans.";
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Bristol N2;
TISSUE=Embryo;
Schmidt S.R., Werner E., Mueller C.R., Kress W.;
"Sequence homology of HGO genes in eukaryotic organisms.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF136150; AAF61419.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U95181; AAD00776.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z93778; CAB07848.4; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL034364; CAB07848.4; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL034364; CAA22255.4; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z93778; CAA22255.4; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T19626; T19626.
T37469; T37469.
RefSeq NP_492433.1; -.
UniGene Cel.19613
3D structure databases
HSSP Q93099; 1EYB. [HSSP ENTRY / PDB]
ModBase Q9Y041.
Protein-protein interaction databases
IntAct Q9Y041; -.
Organism-specific databases
WormBase WBGene00001843; hgo-1.
WormPep W06D4.1; CE29602. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q9Y041; -.
Ontologies
GO
GO:0042802; Molecular function: identical protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q9Y041.
Genome annotation databases
Ensembl W06D4.1; Caenorhabditis elegans. [Contig view]
GeneID 172726; -.
KEGG cel:W06D4.1; -.
NMPDR fig|6239.3.peg.2394; -.
Other
ProtoNet Q9Y041.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   437  437     Homogentisate 1,2-dioxygenase. PRO_0000220243
METAL   336   336        Iron (By similarity). 
METAL   342   342        Iron (By similarity). 
METAL   372   372        Iron (By similarity). 
CONFLICT   156   156        D -> N (in Ref. 2; AAD00776). 
CONFLICT   176   176        L -> P (in Ref. 2; AAD00776). 
CONFLICT   193   193        V -> G (in Ref. 2; AAD00776). 
CONFLICT   242   242        V -> G (in Ref. 2; AAD00776). 
CONFLICT   265   265        D -> E (in Ref. 2; AAD00776). 
CONFLICT   433   433        F -> Y (in Ref. 2; AAD00776). 
Sequence information
Length: 437 AA [This is the length of the unprocessed precursor] Molecular weight: 49239 Da [This is the MW of the unprocessed precursor] CRC64: C14E7077C7CF9703 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSEFDELKYL TGFGNEHATS DPRVPDALPV GQNSPQKCSH GLYAEQLSGT AFTAPRSQNQ 

        70         80         90        100        110        120 
RSWLYRIRPS VIHRPFEAMK ENDQHWTNNF SSIPPNPNQY RWNPFPLPTK EGVTFVDNLY 

       130        140        150        160        170        180 
TVCGGGDVIS RTGLAIHQFS CNASMEHTAM YNSDGDFLIV PQQGALEITT EFGRLLVNPQ 

       190        200        210        220        230        240 
EIAVIPQGIR FSVAVRGPSR GYILEVYGTH FQLPDLGPIG ANGLANPRDF EAPVAWFEDL 

       250        260        270        280        290        300 
DVEFTIINKY QGSWFQAKQG HSPFDVVGWH GNYVPYKYDL KKFMVINTVS FDHCDPSIFT 

       310        320        330        340        350        360 
VLTAPSVKHG TAIADFVIFP PRWGCADNTF RPPYYHRNCM SEYMGLITGC YEAKEGGFKP 

       370        380        390        400        410        420 
GGGSLHSMMT PHGPDFNCFE MASNADLKPQ RVAEGTMSFM FESSLNMAIT NWAVYQNVDK 

       430 
DYYKDWQPLK KHFTMPK
Q9Y041 in FASTA format

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