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UniProtKB/Swiss-Prot entry Q9Y7D2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_ASPTE
Primary accession number Q9Y7D2
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on April 3, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.34
Gene name None
From
Aspergillus terreus [TaxID: 33178] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 20542 / MF4845;
DOI=10.1126/science.284.5418.1368; PubMed=10334994 [NCBI, ExPASy, EBI, Israel, Japan]
Kennedy J., Auclair K., Kendrew S.G., Park C., Vederas J.C., Hutchinson C.R.;
"Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.";
Science 284:1368-1372(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF141925; AAD34556.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase Q9Y7D2.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
IPR000731; SSD_5TM.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PS50156; SSD; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9Y7D2.
Other
ProtoNet Q9Y7D2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol biosynthesis; Endoplasmic reticulum; Glycoprotein; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1048  1048     3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114451
TRANSMEM   221    241  21     Potential. 
TRANSMEM   251    271  21     Potential. 
TRANSMEM   277    297  21     Potential. 
TRANSMEM   349    369  21     Potential. 
TRANSMEM   378    398  21     Potential. 
TRANSMEM   440    460  21     Potential. 
DOMAIN   222    403  182     SSD. 
REGION   461    614  154     Linker. 
REGION   615   1040  426     Catalytic. 
ACT_SITE   729    729        Charge relay system (By similarity). 
ACT_SITE   863    863        Charge relay system (By similarity). 
ACT_SITE   939    939        Charge relay system (By similarity). 
ACT_SITE   1035   1035        Proton donor (By similarity). 
CARBOHYD   436    436        N-linked (GlcNAc...) (Potential). 
CARBOHYD   470    470        N-linked (GlcNAc...) (Potential). 
CARBOHYD   520    520        N-linked (GlcNAc...) (Potential). 
CARBOHYD   793    793        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1039   1039        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 1048 AA [This is the length of the unprocessed precursor] Molecular weight: 112451 Da [This is the MW of the unprocessed precursor] CRC64: 8B7B3098ADA24BDE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDPVVRKPDP GGVQHRVTKA LRAIVGHACR HPIHTLLVTA LTAATTHLHV LEGTYQATHR 

        70         80         90        100        110        120 
GLAPWAKETP LNVQSFLWGS RTVSLGEASA WKWQIDDRPK VPEDGQSDFH WALVTLDLPG 

       130        140        150        160        170        180 
ASVDASIPFL SNTLSGFLGA EQTTPTPDSS PSPDHSALTF RVPYSQLDGF LQAVEIIPSE 

       190        200        210        220        230        240 
KEDDSWRLRS PREEGSPRSL GHWLGSSWLS FLHRVHHAET VDLVIIGLSY LAMNMTVVSL 

       250        260        270        280        290        300 
FRVMRHLGSR FWLAASVLLS GAFAFVLGLG ITTTCDVPVD MLLLFEGIPY LVLTVGFEKP 

       310        320        330        340        350        360 
IQLTRAVLCV SEELWGGGQR QVPNGASSDD SRQNQLIPNI IQLAVDREGW YIVRSYLLEI 

       370        380        390        400        410        420 
GALALGAVLR PKDSLGHFCF LAAWTLLIDA VLLFTFYATI LCVKLEITRI RSPGGLGQVN 

       430        440        450        460        470        480 
AKHPSGIFGH KVKSTNITWW KLLTVGGFVL CHFLQLSPFF YRVMGEYMAN GTLPPTAVSP 

       490        500        510        520        530        540 
FKEAANGLNE IYLTARVEGF ETRVTVLPPL QYVLESAGFN ISATKRSTFD GVLDGLESPL 

       550        560        570        580        590        600 
GRLCLMGALV VSLVLNNHLI HAARWHAWPQ ARESAVPDGS YLSVPCSATA PEVCTRPPEE 

       610        620        630        640        650        660 
TEALLKSNQA ESLTDDELVE LCLRGKIAGY SLEKTLERIA AGSSRSVTRL EAFTRAVRIR 

       670        680        690        700        710        720 
RAAVSKTPST QNLCSGLAES LLPYRDYNYE LVHGACCENV VGYLPLPLGV AGPMVIDGQA 

       730        740        750        760        770        780 
LFIPMATTEG VLVASASRGC KAINAGGGAT TMLKGDGMTR GPCLRFPSAQ RAAEAQRWVE 

       790        800        810        820        830        840 
SPLGHEVLAA AFNATSRFAR LQTLTVAQAG IYLYIRFRTT TGDAMGMNMI SKGVEKALEA 

       850        860        870        880        890        900 
MAAEGGFPDM HTVTLSGNFC SDKKSAAINW IGGRGKSVIA EATIPAETVR QVLKTDVDAL 

       910        920        930        940        950        960 
VELNTAKNLV GSAMAGSLGG FNAHASNLVQ AVFLATGQDP AQNVESSSCI TTMKNIDGNL 

       970        980        990       1000       1010       1020 
HIAVSMPSME VGTIGGGTIL EAQGAMLDLL GVRGAHSTEP GANARRLARI VAAAVLAGEL 

      1030       1040 
STCAALAAGH LVNAHMQHNR SAGATVKK
Q9Y7D2 in FASTA format

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