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UniProtKB/Swiss-Prot entry Q9Z6M4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARODE_CHLPN
Primary accession number Q9Z6M4
Secondary accession number Q9JQ99
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Shikimate biosynthesis protein aroDE
Synonyms None
Includes 3-dehydroquinate dehydratase
     (3-dehydroquinase)
     (EC 4.2.1.10)
     (Type I DHQase)
Shikimate dehydrogenase
     (EC 1.1.1.25)
Gene name
Name: aroE
Synonyms: aroD/E
OrderedLocusNames: CPn_1035, CP_0817, CpB1075
From
Chlamydia pneumoniae (Chlamydophila pneumoniae) [TaxID: 83558] [HAMAP proteome]
Taxonomy Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydophila.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CWL029;
DOI=10.1038/7716; PubMed=10192388 [NCBI, ExPASy, EBI, Israel, Japan]
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
"Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
Nat. Genet. 21:385-389(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AR39;
DOI=10.1093/nar/28.6.1397; PubMed=10684935 [NCBI, ExPASy, EBI, Israel, Japan]
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.";
Nucleic Acids Res. 28:1397-1406(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=J138;
DOI=10.1093/nar/28.12.2311; PubMed=10871362 [NCBI, ExPASy, EBI, Israel, Japan]
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA.";
Nucleic Acids Res. 28:2311-2314(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TW-183;
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001363; AAD19172.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE002161; AAF38612.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000008; BAA99242.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017160; AAP99004.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G72003; G72003.
H86619; H86619.
RefSeq NP_225229.1; -.
NP_301090.1; -.
NP_445356.1; -.
NP_877347.2; -.
3D structure databases
HSSP Q58484; 1NVT. [HSSP ENTRY / PDB]
ModBase Q9Z6M4.
Enzyme and pathway databases
BioCyc CPNE115711:CP_0817-MON; -.
CPNE115713:CPN1035-MON; -.
CPNE138677:CPJ1035-MON; -.
CPNE182082:CPB1075-MON; -.
Ontologies
GO
GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity (inferred from electronic annotation from HAMAP).
GO:0004764; Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073; Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00214; fused; 1.
MF_00222; fused; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR001381; DHquinase_I.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01487; DHquinase_I; 1.
PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.
ProDom PD005337; DHquinase_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00507; aroE; 1.
PROSITE PS01028; DEHYDROQUINASE_I; FALSE_NEG.
BLOCKS Q9Z6M4.
Genome annotation databases
GeneID 1467754; -.
894704; -.
919809; -.
962771; -.
GenomeReviews BA000008_GR; aroE.
AE002161_GR; CP_0817.
AE009440_GR; CpB1075.
AE001363_GR; CPn_1035.
KEGG cpa:CP0817; -.
cpn:CPn1035; -.
cpt:CpB1075; -.
TIGR CP_0817; -.
Phylogenomic databases
HOGENOM Q9Z6M4; -.
Other
ProtoNet Q9Z6M4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Lyase; Multifunctional enzyme; NADP; Oxidoreductase; Schiff base.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   477  477     Shikimate biosynthesis protein aroDE. PRO_0000138823
NP_BIND   339   343  5     NADP (By similarity). 
REGION   1   209  209     3-dehydroquinate dehydratase. 
REGION   210   477  268     Shikimate 5-dehydrogenase. 
ACT_SITE   111   111        Proton acceptor (By similarity). 
ACT_SITE   134   134        Schiff-base intermediate with substrate (By similarity). 
Sequence information
Length: 477 AA [This is the length of the unprocessed precursor] Molecular weight: 52945 Da [This is the MW of the unprocessed precursor] CRC64: 3B57DD86C163E935 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLCATVSGPS FCEAKQQILK SLHLVDIIEL RLDLINELDD QELHTLITTA QNPILTFRQH 

        70         80         90        100        110        120 
KEMSTALWIQ KLYSLAKLEP KWMDIDVSLP KTALQTIRKS HPKIKLILSY HTDKNEDLDA 

       130        140        150        160        170        180 
IYNEMLATPA EIYKIVLSPE NSSEALNYIK KARLLPKPST VLCMGTHGLP SRVLSPLISN 

       190        200        210        220        230        240 
AMNYAAGISA PQVAPGQPKL EELLSYNYSK LSEKSHIYGL IGDPVDRSIS HLSHNFLLSK 

       250        260        270        280        290        300 
LSLNATYIKF PVTIGEVVTF FSAIRDLPFS GLSVTMPLKT AIFDHVDALD ASAQLCESIN 

       310        320        330        340        350        360 
TLVFRNQKIL GYNTDGEGVA KLLKQKNISV NNKHIAIVGA GGAAKAIAAT LAMQGANLHI 

       370        380        390        400        410        420 
FNRTLSSAAA LATCCKGKAY PLGSLENFKT IDIIINCLPP EVTFPWRFPP IVMDINTKPH 

       430        440        450        460        470 
PSPYLERAQK HGSLIIHGYE MFIEQALLQF ALWFPDFLTP ESCDSFRNYV KNFMAKV 

Q9Z6M4 in FASTA format

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