NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/s004250050708; PubMed=10872233 [NCBI, ExPASy, EBI, Israel, Japan]
Hirner A.A., Seitz H.U.;
"Isoforms of chalcone synthase in Daucus carota L. and their differential expression in organs from the European wild carrot and in ultraviolet-A-irradiated cell cultures.";
Planta 210:993-998(2000).

Comments

FUNCTION: The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
CATALYTIC ACTIVITY: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO₂.
PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis .
SIMILARITY: Belongs to the chalcone/stilbene synthases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ006780; CAA07245.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P30074; 1CGZ. [HSSP ENTRY / PDB]

SMR

Q9ZS40; 8-391.

ModBase

Q9ZS40.

Enzyme and pathway databases

BRENDA

2.3.1.74; 1081.

Ontologies

GO:0008415;	Molecular function: acyltransferase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0016210;	Molecular function: naringenin-chalcone synthase activity (inferred from electronic annotation from EC).
GO:0009813;	Biological process: flavonoid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR012328; Chal_sti_synt_C.
IPR018088; Chalcone/stilbene_synthase_AS.
IPR001099; Chalcone/stilbene_synthase_N.
IPR011141; Polyketide_synthase_type-III.
IPR016038; Thiolase-like_subgr.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.47.10; Thiolase-like_subgr; 2.

Pfam

PF02797; Chal_sti_synt_C; 1.
PF00195; Chal_sti_synt_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000451; PKS_III; 1.

ProDom

PD000453; N-C_synthase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00441; CHALCONE_SYNTH; 1.

Other

ProtoNet

Q9ZS40.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acyltransferase; Flavonoid biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 397`	`397`	`Chalcone synthase 2.`	`PRO_0000215971`
`ACT_SITE`	`168 168`		`By similarity.`

Sequence information

Length: 397 AA [This is the length of the unprocessed precursor]

Molecular weight: 43559 Da [This is the MW of the unprocessed precursor]

CRC64: 9386F44B9132EDEE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MANHNAEIEE IRKRQRAQGP ANILAIGTAT PSNCVYQADY PDYYFRITNS EHMSDLKLKF 

        70         80         90        100        110        120 
KRMCEKSMIR KRYMHITEEY LKENPNVCAY EAPSLDARQD LVVVEVPRLG KEAAAKAIKE 

       130        140        150        160        170        180 
WGHPKSKITH LIFCTTSGVD MPGADYQLTK LLGLRPSVKR FMMYQQGCFA GGTVLRLAKD 

       190        200        210        220        230        240 
LAENNTGARV LVVCSEITAV TFRGPSDSHL DSLVGQALFG DGAAAVIVGS DPDLSVERPL 

       250        260        270        280        290        300 
FQLISAAQTI LPDSDGAIDG HLREVGLTFH LLKDVPGLIS KNIEKSLKEA FGPIGISDWN 

       310        320        330        340        350        360 
SLFWIAHPGG PAILDQVELK LGLKEEKMRA TRQVLSDYGN MSSACVLFIL DEMRKKSIEE 

       370        380        390 
GKATTGDGLD WGVLFGFGPG LTVETVVLHS VPATITH

Q9ZS40 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools