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HAMAP annotation rule: MF_00051

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General rule information

Accession MF_00051
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 36)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_00051_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00051_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00051_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00051_A]
end case

Names SHMT


Propagated annotation

Identifier, protein and gene names
Identifier GLYA
Protein name
RecName: Full=Serine hydroxymethyltransferase;
Short=Serine methylase;
Short=SHMT;
EC=2.1.2.1;
Gene name glyA
Comments
FUNCTION: Interconversion of serine and glycine (By similarity).
CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
COFACTOR: Pyridoxal phosphate (By similarity).
PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.

case <OC:Bacteria>
SUBUNIT: Homotetramer (By similarity).
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the SHMT family.
Cross-references
Pfam PF00464; SHMT; 1;
PROSITE PS00096; SHMT; 1;
Keywords

case <FT:2> or <FT:3> or <FT:4> or <FT:5> or <FT:6>
Acetylation.
end case

Cytoplasm, One-carbon metabolism, Pyridoxal phosphate, Transferase.
Gene Ontology
GO:0004372; Molecular function: glycine hydroxymethyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
GO:0009069; Biological process: serine family amino acid metabolic process.
GO:0005737; Cellular component: cytoplasm.
Features

case <OC:Bacteria>
From: GLYA_ECOLI (P0A825)
Key     From     To       Description   Condition   FTGroup
MOD_RES     229     229       N6-(pyridoxal phosphate)lysine (By similarity)   K  
end case

case <OC:Escherichia> or <OC:Shigella>
Key     From     To       Description   Condition   FTGroup
MOD_RES     54     54       N6-acetyllysine (By similarity)   K  
MOD_RES     250     250       N6-acetyllysine (By similarity)   K  
MOD_RES     285     285       N6-acetyllysine (By similarity)   K  
MOD_RES     354     354       N6-acetyllysine (By similarity)   K  
MOD_RES     375     375       N6-acetyllysine (By similarity)   K  
end case

case <OC:Archaea>
From: GLYA_METJA (Q58992)
Key     From     To       Description   Condition   FTGroup
MOD_RES     226     226       N6-(pyridoxal phosphate)lysine (By similarity)   K  
end case



Additional information


case <OC:Bacteria>
Size range: 406-574 amino acids
end case


case <OC:Archaea>
Size range: 412-442 amino acids
end case

Related UniRules: None
Template: P0A825 (GLYA_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in AGRT5, BORBR, BORPA, BURMA, BURP1, BURPS, BURS3, BURTA, COLP3, ERWCT, HAHCH, MYCBO, MYCTU, PHOPR, PSE14, PSEAE, PSEF5, PSEPF, PSEPK, PSESM, PSEU2, RALEJ, RALSO, RHILO, RHIME, RHOPA, RHORT, SILPO, SULDN, VIBCH, VIBPA, VIBVU, VIBVY
Plasmid encoded: None
Comments: Possible wrong start in ARCFU and HALSA. Possible C-terminal problem in TREPA.

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UniProtKB rule member sequences