ExPASy Proteomics Server

Accession	MF_00113
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00113; [distribution of match scores in UniProtKB];[seed alignment for MF_00113]

Names

QueA

Identifier

QUEA

Protein name

RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase; EC=5.-.-.-; AltName: Full=Queuosine biosynthesis protein queA;

Gene name

queA

FUNCTION: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity).

CATALYTIC ACTIVITY: S-adenosylmethionine + 7-aminomethyl-7-deazaguanosine = methionine + adenine + epoxyqueuosine.

PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the queA family.

Pfam	PF02547; Queuosine_synth; 1;
TIGRFAMs	TIGR00113; queA; 1;

Cytoplasm, Queuosine biosynthesis, Transferase, Isomerase.

GO:0016853; Molecular function: isomerase activity.
GO:0016740; Molecular function: transferase activity.
GO:0008616; Biological process: queuosine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	334-408 amino acids
Related UniRules:	None
Template:	P0A7F9 (QUEA_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	RPE-type insertion in RICCN and RICPR. Probable wrong start in ANASP and DEIRA.