ExPASy Proteomics Server

Accession	MF_00227
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 14)

Data class

Protein

Predictors

HAMAP; MF_00227; [distribution of match scores in UniProtKB];[seed alignment for MF_00227]

Names

RNase_P

Identifier

RNPA

Protein name

RecName: Full=Ribonuclease P protein component; Short=RNaseP protein; Short=RNase P protein; EC=3.1.26.5; AltName: Full=Protein C5;

Gene name

rnpA

FUNCTION: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity).

CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

SUBUNIT: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit (By similarity).

SIMILARITY: Belongs to the rnpA family.

Pfam	PF00825; Ribonuclease_P; 1;
TIGRFAMs	TIGR00188; rnpA; 1;
PROSITE	PS00648; RIBONUCLEASE_P; 1;

Hydrolase, Nuclease, Endonuclease, tRNA processing, RNA-binding.

GO:0004526; Molecular function: ribonuclease P activity.
GO:0000049; Molecular function: tRNA binding.
GO:0001682; Biological process: tRNA 5'-leader removal.

Size range:	108-166 amino acids
Related UniRules:	None
Template:	P25814 (RNPA_BACSU); P0A0H5 (RNPA_STAAU): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None