ExPASy Proteomics Server

Accession	MF_00504
Dates	3-DEC-2001 (Created) 25-NOV-2009 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00504; [distribution of match scores in UniProtKB];[seed alignment for MF_00504]

Names

Aminopeptidase_M17

Identifier

PEPB

Protein name

RecName: Full=Peptidase B; EC=3.4.11.23; AltName: Full=Aminopeptidase B;

Gene name

pepB

FUNCTION: Probably plays an important role in intracellular peptide degradation (By similarity).

CATALYTIC ACTIVITY: Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.

COFACTOR: Binds 2 manganese ions per subunit (By similarity).

SUBUNIT: Homohexamer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the peptidase M17 family.

Pfam	PF00883; Peptidase_M17; 1;
PRINTS	PR00481; LAMNOPPTDASE; 1;
PROSITE	PS00631; CYTOSOL_AP; 1;

Cytoplasm, Hydrolase, Protease, Aminopeptidase, Manganese, Metal-binding.

GO:0004177; Molecular function: aminopeptidase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0006508; Biological process: proteolysis.
GO:0005737; Cellular component: cytoplasm.

From: PEPB_ECOLI (P37095)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		207		207		Potential		K
ACT_SITE		281		281		Potential		R
METAL		195		195		Manganese 2 (By similarity)		K
METAL		200		200		Manganese 1 (By similarity)		D
METAL		200		200		Manganese 2 (By similarity)		D
METAL		218		218		Manganese 2 (By similarity)		D
METAL		277		277		Manganese 1 (By similarity)		D
METAL		279		279		Manganese 1 (By similarity)		E
METAL		279		279		Manganese 2 (By similarity)		E

Size range:	427-456 amino acids
Related UniRules:	MF_00181 (AMPA)
Template:	P37095 (PEPB_ECOLI); Q9RF52 (PEPB_SALTY): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None