ExPASy Proteomics Server

Accession	MF_01129
Dates	22-JUL-2003 (Created) 25-NOV-2009 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_01129; [distribution of match scores in UniProtKB];[seed alignment for MF_01129]

Names

H_PPase_type1

Identifier

HPPA

Protein name

RecName: Full=Pyrophosphate-energized proton pump; EC=3.6.1.1; AltName: Full=Pyrophosphate-energized inorganic pyrophosphatase; Short=H(+)-PPase; AltName: Full=Membrane-bound proton-translocating pyrophosphatase;

Gene name

hppA

FUNCTION: Generates a proton motive force; it probably catalyzes a fully reversible reaction, thus being able to synthesize pyrophosphate when the proton motive force is sufficient (By similarity).

CATALYTIC ACTIVITY: Diphosphate + H(2)O = 2 phosphate.

COFACTOR: Magnesium (By similarity).

COFACTOR: Potassium (By similarity).

SUBUNIT: Homodimer (Potential).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. Type 1 subfamily.

Pfam	PF03030; H_PPase; 1;
TIGRFAMs	TIGR01104; V_PPase; 1;
General	Transmembrane; -; 13-15; trigger=Yes;

Transport, Ion transport, Hydrogen ion transport, Hydrolase, Magnesium, Potassium, Cell membrane, Membrane, Transmembrane.

GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005886; Cellular component: plasma membrane.

From: HPPA_THEMA (Q9S5X0)
Key		From		To		Description		Condition		FTGroup
SITE		495		495		Determinant of potassium dependence (By similarity)		A		1

Size range:	671-734 amino acids
Related UniRules:	MF_01130 (HPPA)
Template:	Q9S5X0 (HPPA_THEMA)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None