ExPASy Proteomics Server

Accession	MF_01142
Dates	2-MAR-2004 (Created) 25-NOV-2009 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_01142; [distribution of match scores in UniProtKB];[seed alignment for MF_01142]

Names

LrgB

Identifier

LRGB

Protein name

RecName: Full=Antiholin-like protein lrgB;

Gene name

lrgB

FUNCTION: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with lrgB, with the holin-like proteins cidA and/or cidB. The lrgAB and cidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity).

FUNCTION: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with lrgA, with the holin-like protein cidA. The lrgAB and cidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).

SIMILARITY: Belongs to the cidB/lrgB family. LrgB subfamily.

Pfam	PF04172; LrgB; 1;
General	Transmembrane; -; 5-7; trigger=Yes;

Cell membrane, Cytolysis, Membrane, Transmembrane.

GO:0019835; Biological process: cytolysis.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.

Size range:	230-233 amino acids
Related UniRules:	None
Template:	P60637 (CIDB_STAAM)
Scope:	Bacteria; Bacillales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None