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| HAMAP annotation rule: MF_01182 |
| Accession | MF_01182 |
| Dates | 24-NOV-2006 (Created) 25-NOV-2009 (Last updated, Version 15) |
| Data class | Protein |
| Predictors | HAMAP; MF_01182; [distribution of match scores in UniProtKB];[seed alignment for MF_01182] |
| Names | Cytochrom_C552 |
| Identifier | NRFA |
| Protein name |
|
| Gene name | nrfA |
FUNCTION: Plays a role in nitrite reduction (By similarity).
CATALYTIC ACTIVITY: NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+).
case <FTGroup:2>
COFACTOR: Binds 1 calcium ion per monomer (By similarity).
end case
case <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
COFACTOR: Binds 5 heme groups covalently per monomer (By similarity).
end case
PATHWAY: Nitrogen metabolism; nitrate reduction (assimilation).
SUBCELLULAR LOCATION: Periplasm (By similarity).
SIMILARITY: Belongs to the cytochrome c-552 family.
| PROSITE |
PS51008; MULTIHEME_CYTC; 1; |
| Pfam |
PF02335; Cytochrom_C552; 1; |
| General |
Signal; -; 1; trigger=Yes; |
case <FTGroup:2>
end case
case <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
Heme.
end case
case <FTGroup:1>
end case
case <FTGroup:2>
GO:0005509; Molecular function: calcium ion binding.
end case
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0042279; Molecular function: nitrite reductase (cytochrome, ammonia-forming) activity.
GO:0006807; Biological process: nitrogen compound metabolic process.
GO:0055114; Biological process: oxidation reduction.
GO:0042597; Cellular component: periplasmic space.
GO:0006807; Biological process: nitrogen compound metabolic process.
GO:0055114; Biological process: oxidation reduction.
GO:0042597; Cellular component: periplasmic space.
| From: NRFA_ECOLI (P0ABK9) | ||||||||||
| Key | From | To | Description | Condition | FTGroup | |||||
| METAL | 94 | 94 | Iron (heme 3 axial ligand) (By similarity) | H | 1 | |||||
| METAL | 126 | 126 | Iron (heme 1 axial ligand) (By similarity) | K | 1 | |||||
| METAL | 164 | 164 | Iron (heme 2 axial ligand) (By similarity) | H | 1 | |||||
| METAL | 213 | 213 | Iron (heme 3 axial ligand) (By similarity) | H | 1 | |||||
| METAL | 215 | 215 | Calcium (By similarity) | E | 2 | |||||
| METAL | 216 | 216 | Calcium; via carbonyl oxygen (By similarity) | Y | 2 | |||||
| METAL | 261 | 261 | Calcium; via carbonyl oxygen (By similarity) | K | 2 | |||||
| METAL | 263 | 263 | Calcium (By similarity) | Q | 2 | |||||
| METAL | 275 | 275 | Iron (heme 5 axial ligand) (By similarity) | H | 1 | |||||
| METAL | 286 | 286 | Iron (heme 4 axial ligand) (By similarity) | H | 1 | |||||
| METAL | 301 | 301 | Iron (heme 2 axial ligand) (By similarity) | H | 1 | |||||
| METAL | 318 | 318 | Iron (heme 5 axial ligand) (By similarity) | H | 1 | |||||
| METAL | 393 | 393 | Iron (heme 4 axial ligand) (By similarity) | H | 1 | |||||
| BINDING | 122 | 122 | Heme 1 (covalent) (By similarity) | C | 3 | |||||
| BINDING | 125 | 125 | Heme 1 (covalent) (By similarity) | C | 3 | |||||
| BINDING | 160 | 160 | Heme 2 (covalent) (By similarity) | C | 4 | |||||
| BINDING | 163 | 163 | Heme 2 (covalent) (By similarity) | C | 4 | |||||
| BINDING | 209 | 209 | Heme 3 (covalent) (By similarity) | C | 5 | |||||
| BINDING | 212 | 212 | Heme 3 (covalent) (By similarity) | C | 5 | |||||
| BINDING | 216 | 216 | Substrate (By similarity) | Y | ||||||
| BINDING | 264 | 264 | Substrate (By similarity) | H | ||||||
| BINDING | 282 | 282 | Heme 4 (covalent) (By similarity) | C | 6 | |||||
| BINDING | 285 | 285 | Heme 4 (covalent) (By similarity) | C | 6 | |||||
| BINDING | 314 | 314 | Heme 5 (covalent) (By similarity) | C | 7 | |||||
| BINDING | 317 | 317 | Heme 5 (covalent) (By similarity) | C | 7 | |||||
| Size range: | 463-538 amino acids |
| Related UniRules: | None |
| Template: | P0ABK9 (NRFA_ECOLI) |
| Scope: | Bacteria; Bacteroidetes Bacteria; Proteobacteria |
| Fusion: | Nter: None; Cter: None |
| Duplicate: | None |
| Plasmid encoded: | None |
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