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HAMAP annotation rule: MF_01422

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General rule information

Accession MF_01422
Dates 2-FEB-2005 (Created)
25-NOV-2009 (Last updated, Version 12)
Data class Protein
Predictors HAMAP; MF_01422; [distribution of match scores in UniProtKB];[seed alignment for MF_01422]
Names MdtA


Propagated annotation

Identifier, protein and gene names
Identifier MDTA
Protein name
RecName: Full=Multidrug resistance protein mdtA;
AltName: Full=Multidrug transporter mdtA;
Flags: Precursor;
Gene name mdtA
Comments

case <OC:Escherichia>
FUNCTION: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate (By similarity).
end case

SUBUNIT: Part of a tripartite efflux system composed of mdtA, mdtB and mdtC (By similarity).
SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein (Potential).

case <OC:Escherichia>
INDUCTION: The mdtABC operon is transcriptionally activated by baeR.
end case

SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
Cross-references
Pfam PF00529; HlyD; 1;
TIGRFAMs TIGR01730; RND_mfp; 1;
General Signal; -; 1; trigger=Yes;
Keywords
Cell membrane, Cell inner membrane, Membrane, Transport.
Gene Ontology
GO:0005215; Molecular function: transporter activity.
GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 401-444 amino acids
Related UniRules: None
Template: P76397 (MDTA_ECOLI)
Scope: Bacteria; Enterobacteriaceae
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None
Comments: The sequence of Shigella flexneri is shorter but it is impossible to correct the sequence.

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UniProtKB rule member sequences