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| HAMAP annotation rule: MF_01672 |
| Accession | MF_01672 |
| Dates | 29-SEP-2008 (Created) 25-NOV-2009 (Last updated, Version 3) |
| Data class | Protein |
| Predictors | HAMAP; MF_01672; [distribution of match scores in UniProtKB];[seed alignment for MF_01672] |
| Names | IolE |
| Identifier | IOLE |
| Protein name |
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| Gene name | iolE |
FUNCTION: Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol) (By similarity).
CATALYTIC ACTIVITY: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H(2)O.
COFACTOR: Glutathione (By similarity).
COFACTOR: Cobalt or manganese (By similarity).
case <OC:Firmicutes>
PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7.
end case
SIMILARITY: Belongs to the iolE/mocC family.
| Pfam |
PF01261; AP_endonuc_2; 1; |
GO:0030145; Molecular function: manganese ion binding.
GO:0050114; Molecular function: myo-inosose-2 dehydratase activity.
GO:0019310; Biological process: inositol catabolic process.
GO:0050114; Molecular function: myo-inosose-2 dehydratase activity.
GO:0019310; Biological process: inositol catabolic process.
| Size range: | 297-308 amino acids |
| Related UniRules: | None |
| Template: | P42416 (IOLE_BACSU) |
| Scope: | Bacteria; Firmicutes Bacteria; Gammaproteobacteria Bacteria; Tenericutes |
| Fusion: | Nter: None; Cter: None |
| Duplicate: | in BACCZ |
| Plasmid encoded: | in BACCZ |
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